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Association of STAT6 gene variants with food allergy diagnosed by double‐blind placebo‐controlled food challenges
Author(s) -
Ginkel C. D.,
Pettersson M. E.,
Dubois A. E. J.,
Koppelman G. H.
Publication year - 2018
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.13432
Subject(s) - food allergy , allergy , medicine , immunology , snp , allele , placebo , peanut allergy , single nucleotide polymorphism , gene , biology , genotype , genetics , pathology , alternative medicine
This study describes the role of two STAT 6 gene variants in food allergy using data of patients and their parents who underwent double‐blind placebo‐controlled food challenges ( DBPCFC s). After quality control, 369 trios were analysed including 262 children (71.0%) with food allergy. Associations were tested by the Family based association test. The A alleles of both SNP s were associated with food allergy ( P = .036 and P = .013 for rs324015 and rs1059513, respectively). Furthermore, these A alleles were associated with peanut allergy, higher sIgE levels to both peanut and cow's milk, more severe symptoms and higher eliciting doses during peanut and cow's milk DBPCFC s (all P < .05). In silico analysis indicates that the identified risk variants increase STAT 6 expression which stimulates the differentiation of CD 4 + T cells to the Th2 subset. In conclusion, STAT 6 variants may be involved in the pathophysiology of food allergy and their role seems to be independent of the allergenic food.