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This study describes the role of two   STAT 6  gene variants in food allergy using data of patients and their parents who underwent double‐blind placebo‐controlled food challenges ( DBPCFC s). After quality control, 369 trios were analysed including 262 children (71.0%) with food allergy. Associations were tested by the Family based association test. The A alleles of both  SNP s were associated with food allergy ( P  = .036 and  P  = .013 for rs324015 and rs1059513, respectively). Furthermore, these A alleles were associated with peanut allergy, higher  sIgE  levels to both peanut and cow's milk, more severe symptoms and higher eliciting doses during peanut and cow's milk  DBPCFC s (all  P  < .05). In silico analysis indicates that the identified risk variants increase   STAT 6  expression which stimulates the differentiation of  CD 4 +  T cells to the Th2 subset. In conclusion,   STAT 6  variants may be involved in the pathophysiology of food allergy and their role seems to be independent of the allergenic food.

Association of STAT6 gene variants with food allergy diagnosed by double‐blind placebo‐controlled food challenges