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The burden of chronic spontaneous urticaria is substantial: Real‐world evidence from ASSURE ‐ CSU
Author(s) -
Maurer M.,
Abuzakouk M.,
Bérard F.,
Caica W.,
Oude Elberink H.,
GiménezArnau A.,
Grattan C.,
Hollis K.,
Knulst A.,
Lacour J.P.,
Lynde C.,
Marsland A.,
McBride D.,
Nakonechna A.,
Ortiz de Frutos J.,
Proctor C.,
Sussman G.,
Sweeney C.,
Tian H.,
Weller K.,
Wolin D.,
Balp M.M.
Publication year - 2017
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.13209
Subject(s) - medicine , angioedema , dermatology life quality index , quality of life (healthcare) , disease , cohort , chronic urticaria , observational study , medical record , cohort study , nursing
Background Chronic spontaneous urticaria ( CSU ) can be debilitating, difficult to treat, and frustrating for patients and physicians. Real‐world evidence for the burden of CSU is limited. The objective of this study was to document disease duration, treatment history, and disease activity, as well as impact on health‐related quality of life ( HRQ oL) and work among patients with inadequately controlled CSU , and to describe its humanistic, societal, and economic burden. Methods This international observational study assessed a cohort of 673 adult patients with CSU whose symptoms persisted for ≥12 months despite treatment. Demographics, disease characteristics, and healthcare resource use in the previous 12 months were collected from medical records. Patient‐reported data on urticaria and angioedema symptoms, HRQ oL, and work productivity and activity impairment were collected from a survey and a diary. Results Almost 50% of patients had moderate‐to‐severe disease activity as reported by Urticaria Activity Score. Mean ( SD ) Dermatology Life Quality Index and Chronic Urticaria Quality of Life Questionnaire scores were 9.1 (6.62) and 33.6 (20.99), respectively. Chronic spontaneous urticaria markedly interfered with sleep and daily activities. Angioedema in the previous 12 months was reported by 66% of enrolled patients and significantly affected HRQ oL. More than 20% of patients reported ≥1 hour per week of missed work; productivity impairment was 27%. These effects increased with increasing disease activity. Significant healthcare resources and costs were incurred to treat CSU . Conclusions Chronic spontaneous urticaria has considerable humanistic and economic impacts. Patients with greater disease activity and with angioedema experience greater HRQ oL impairments.