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Committed mast cell progenitors in mouse blood differ in maturity between T h1 and T h2 strains
Author(s) -
Dahlin J. S.,
Heyman B.,
Hallgren J.
Publication year - 2013
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/all.12223
Subject(s) - progenitor cell , mast cell , bone marrow , biology , immunology , population , progenitor , phenotype , microbiology and biotechnology , stem cell , medicine , genetics , gene , environmental health
Abstract Mast cell progenitors ( MC p) leave the bone marrow and migrate to peripheral tissues where they mature. Although the existence of committed MC p in adult mouse and human blood has been postulated, they have never been found. We have isolated a rare population of cells in adult mouse blood, committed to the mast cell lineage. These were identified as lineage − c‐kit hi ST 2 + integrin β7 hi CD 16/32 hi cells. Moreover, a major difference in maturity of these cells based on F cε RI expression was observed between the T h2‐prone BALB /c strain and the T h1‐prone C 57 BL /6 strain (66% vs 25% Fcε RI + , respectively). Therefore, the choice of mouse strain is critical when studying disease models such as experimental asthma where mast cells and their progenitors are involved.