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Human papillomavirus and posttransplantation cutaneous squamous cell carcinoma: A multicenter, prospective cohort study
Author(s) -
Bouwes Bavinck Jan N.,
Feltkamp Mariet C. W.,
Green Adele C.,
Fiocco Marta,
Euvrard Sylvie,
Harwood Catherine A.,
Nasir Shaaira,
Thomson Jason,
Proby Charlotte M.,
Naldi Luigi,
Diphoorn Janouk C. D.,
Venturuzzo Anna,
Tessari Gianpaolo,
Nindl Ingo,
Sampogna Francesca,
Abeni Damiano,
Neale Rachel E.,
Goeman Jelle J.,
Quint Koen D.,
Halk Anne B.,
Sneek Carmen,
Genders Roel E.,
de Koning Maurits N. C.,
Quint Wim G. V.,
Wieland Ulrike,
Weissenborn Sönke,
Waterboer Tim,
Pawlita Michael,
Pfister Herbert
Publication year - 2018
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1111/ajt.14537
Subject(s) - medicine , hazard ratio , prospective cohort study , basal cell carcinoma , confidence interval , proportional hazards model , oncology , basal cell
Organ transplant recipients ( OTRs ) have a 100‐fold increased risk of cutaneous squamous cell carcinoma ( cSCC ). We prospectively evaluated the association between β genus human papillomaviruses (β PV ) and keratinocyte carcinoma in OTRs . Two OTR cohorts without cSCC were assembled: cohort 1 was transplanted in 2003‐2006 (n = 274) and cohort 2 was transplanted in 1986‐2002 (n = 352). Participants were followed until death or cessation of follow‐up in 2016. β PV infection was assessed in eyebrow hair by using polymerase chain reaction –based methods. β PV IgG seroresponses were determined with multiplex serology. A competing risk model with delayed entry was used to estimate cumulative incidence of histologically proven cSCC and the effect of β PV by using a multivariable Cox regression model. Results are reported as adjusted hazard ratios ( HRs ). OTRs with 5 or more different β PV types in eyebrow hair had 1.7 times the risk of cSCC vs OTRs with 0 to 4 different types ( HR 1.7, 95% confidence interval 1.1‐2.6). A similar risk was seen with high β PV loads ( HR 1.8, 95% confidence interval 1.2‐2.8). No significant associations were seen between serum antibodies and cSCC or between β PV and basal cell carcinoma. The diversity and load of β PV types in eyebrow hair are associated with cSCC risk in OTRs , providing evidence that β PV is associated with cSCC carcinogenesis and may present a target for future preventive strategies.