Premium
CXCL 10 and IL ‐6: Markers of two different forms of intra‐amniotic inflammation in preterm labor
Author(s) -
Romero Roberto,
Chaemsaithong Piya,
Chaiyasit Noppadol,
Docheva Nikolina,
Dong Zhong,
Kim Chong Jai,
Kim Yeon Mee,
Kim JungSun,
Qureshi Faisal,
Jacques Suzanne M.,
Yoon Bo Hyun,
Chaiworapongsa Tinnakorn,
Yeo Lami,
Hassan Sonia S.,
Erez Offer,
Korzeniewski Steven J.
Publication year - 2017
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12685
Subject(s) - chorioamnionitis , prom , amniotic fluid , medicine , inflammation , fetus , obstetrics , gastroenterology , pregnancy , preterm labor , andrology , immunology , biology , genetics
Problem To determine whether amniotic fluid ( AF ) CXCL 10 concentration is associated with histologic chronic chorioamnionitis in patients with preterm labor ( PTL ) and preterm prelabor rupture of the membranes ( PROM ). Method of Study This study included 168 women who had an episode of PTL or preterm PROM . AF interleukin (IL)‐6 and CXCL 10 concentrations were determined by immunoassay. Results (i) Increased AF CXCL 10 concentration was associated with chronic ( OR : 4.8; 95% CI : 1.7‐14), but not acute chorioamnionitis; (ii) increased AF IL ‐6 concentration was associated with acute ( OR : 4.2; 95% CI : 1.3‐13.7) but not chronic chorioamnionitis; and (iii) an increase in AF CXCL 10 concentration was associated with placental lesions consistent with maternal anti‐fetal rejection ( OR : 3.7; 95% CI : 1.3‐10.4). (iv) All patients with elevated AF CXCL 10 and IL ‐6 delivered preterm. Conclusion Increased AF CXCL 10 concentration is associated with chronic chorioamnionitis or maternal anti‐fetal rejection, whereas increased AF IL ‐6 concentration is associated with acute histologic chorioamnionitis.