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Deviant smooth pursuit in preschool children exposed prenatally to methadone or buprenorphine and tobacco affects integrative visuomotor capabilities
Author(s) -
Melinder Annika,
Konijnenberg Carolien,
Sarfi Monica
Publication year - 2013
Publication title -
addiction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.424
H-Index - 193
eISSN - 1360-0443
pISSN - 0965-2140
DOI - 10.1111/add.12267
Subject(s) - smooth pursuit , buprenorphine , methadone , eye movement , cognition , psychology , eye tracking , developmental psychology , addiction , medicine , audiology , pediatrics , opioid , psychiatry , neuroscience , receptor , physics , optics
Background and aims Although an increasing number of children are born to mothers in opioid maintenance therapy ( OMT ), little is known about the long‐term effects of these opioids. Previous studies suggest an association between prenatal OMT exposure and difficulties in eye movement control. Also, the effects of tobacco smoking on eye movements have been reported. The present study examined the influence of eye movements, i.e. smooth pursuit, on visuomotor capabilities in children of smoking mothers in OMT . Design The study comprised a 2 ( OMT versus contrast group) × 2 (slow versus fast smooth pursuit) between‐subject factorial design. Setting The cognitive developmental research unit at the U niversity of O slo, N orway. Participants Participants were 26 4‐year‐old children of tobacco‐smoking women in OMT and 23 non‐exposed 4‐year‐old children, with non‐smoking mothers, matched by gender and age. Measurement Eye movements and smooth pursuit were recorded using a T obii 1750 eyetracker. Visuomotor functions were examined by B ender test. Findings The OMT group tracked slowly moving objects with smooth pursuit in a similar manner to their non‐exposed peers. When fast smooth pursuit was measured, the OMT group of children tracked the object more slowly than the contrast group, P = 0.02, η p 2 = 0.11. A regression analysis showed that fast smooth pursuit predicted children's performance on a visuomotor task, R 2 = 0.37. Conclusion Impaired eye‐tracking skills in 4‐year‐old children exposed to methadone or buprenorphine and tobacco prenatally could inhibit the development of some cognitive functions in later life.