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Abnormality of Very Long‐Chain Fatty Acids of Erythrocyte Membrane in Alcoholic Patients
Author(s) -
Adachi Junko,
Miwa Atsuko,
Ueno Yasuhiro,
Asano Migiwa,
Naito Takeaki,
Imamichi Hiroyuki,
Tatsuno Yoshitsugu
Publication year - 1998
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/acer.1998.22.s3_part1.103s
Subject(s) - peroxisome , chemistry , fatty acid , biochemistry , erythrocyte membrane , alcohol , membrane , chromatography , gene
Profiles of very long‐chain fatty acids were studied in the erythrocyte membrane of five alcoholic patients. We identified three fatty acids as cis ‐16‐pentacosenoic acid (C25:1), cis ‐17‐hexacosenoic acid (C26:1), and hexacosenoic acid (C26:1), and hexacosanoic acid (C26:0) by gas chromatography‐mass spectrometry. The ratios of C26:1/C22:0, C26:0/C22:0, C24:1/C22:0, and C24:0/C22:0 were increased. These findings suggest that active oxygen species or free radicals generated by chronic alcohol consumption in alcohol patients interupt the peroxisomal β ‐oxidation of fatty acids, because very long‐chain fatty acids are mainly metabolized by the peroxisomal β ‐oxidation system. This is the first study showing accumulation of very long‐chain fatty acids in the erythrocyte membrane of alcoholic patients.