Open AccessRelationship between consolidation tumor ratio and tumor‐infiltrating lymphocytes in small‐sized lung adenocarcinoma
Author(s) -
Ono Yuki,
Tagawa Tetsuzo,
Kinoshita Fumihiko,
Haratake Naoki,
Takada Kazuki,
Kohno Mikihiro,
Takenaka Tomoyoshi,
Kamitani Takeshi,
Shimokawa Mototsugu,
Oda Yoshinao,
Mori Masaki,
Yoshizumi Tomoharu
Publication year - 2022
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.14524
Subject(s) - medicine , adenocarcinoma , consolidation (business) , lung , adenocarcinoma of the lung , lung tumor , pathology , oncology , cancer , accounting , business
Background Consolidation tumor ratio (CTR) is associated with cancer progression and histological invasiveness in lung adenocarcinoma (LAD). However, little is known about the association between CTR and immune‐related factors, including tumor‐infiltrating lymphocytes (TILs) density or tumor expression of programmed death ligand 1 (PD‐L1) and indoleamine 2,3‐dioxygenase 1 (IDO1) in small‐sized LAD. Methods This study included 258 patients with LAD (<3 cm) who underwent surgery. Patients were assigned to four groups: CTR = 0; 0 < CTR <0.5; 0.5 ≤ CTR <1 (ground‐glass opacity [GGO] group); and CTR = 1 (pure‐solid group). CD4 + , CD8 + , and FoxP3 + TIL density and PD‐L1 and IDO1 tumor expression were assessed by immunohistochemistry. Results Among the GGO group, CD8 + and FoxP3 + TIL density increased significantly with increasing CTR ( p < 0.001 and p < 0.001, respectively). Moreover, PD‐L1 and IDO1 expression was significantly higher in the pure‐solid group than in the GGO group ( p < 0.001 and p < 0.001, respectively). Conclusions CTR was correlated with the abundance of CD8 + and FoxP3 + TILs in the GGO group. PD‐L1 and IDO1 positivity rates were significantly higher in the pure‐solid group than in the GGO group. Increased CTR may be correlated with immunosuppressive condition.