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Tyrosine kinase inhibitors (TKIs) are the standard treatment for epidermal growth factor receptor (EGFR)‐mutant advanced‐stage non‐small cell lung cancer (NSCLC). However, TKIs can cause some severe adverse events, which are more prevalent within first‐generation EGFR‐TKI use than with second‐generation inhibitors. Herein, we report a case of a patient with advanced‐stage  EGFR ‐mutant NSCLC who developed drug reaction with eosinophilia and systemic symptoms (DRESS) after receiving treatment with afatinib. The patient was successfully rechallenged with erlotinib, without manifestations of skin rash in the following 6 months. Hence, erlotinib may be considered a potential substitute for other EGFR‐TKIs following DRESS occurrence.

thoracic cancer

Successful erlotinib rechallenge in an   EGFR ‐mutant  metastatic  non‐small  cell lung cancer patient with  afatinib‐induced  drug rash with eosinophilia and systemic symptoms: A case report