Open AccessEndostar ( rh‐endostatin ) improves efficacy of concurrent chemoradiotherapy for locally advanced non‐small cell lung cancer: A systematic review and meta‐analysis
Author(s) -
Yuan Meng,
Zhai Yirui,
Men Yu,
Wang Jianyang,
Deng Lei,
Wang Wenqing,
Bao Yongxing,
Yang Xu,
Sun Shuang,
Ma Zeliang,
Liu Yunsong,
Wang Jun,
Zhu Hui,
Hui Zhouguang
Publication year - 2021
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.14188
Subject(s) - medicine , oncology , meta analysis , adverse effect , lung cancer , chemoradiotherapy , relative risk , clinical endpoint , randomized controlled trial , cancer , confidence interval
Background We aimed to clarify the benefits of the addition of rh‐endostatin into concurrent chemoradiotherapy (CCRT) versus CCRT alone for locally advanced non‐small cell lung cancer (NSCLC) by a meta‐analysis. Methods PubMed, Embase, Cochrane Central Register of Controlled Trials, Wanfang and Chinese National Knowledge Infrastructure (CNKI) were systematically screened from inception to November 2020 using the prespecified terms. Prospective trials (evaluating or) comparing the efficacy of endostar combined with CCRT and CCRT for locally advanced NSCLC were included. The primary endpoints were risk ratios (RRs) for objective response rate (ORR) and disease control rate (DCR). The secondary endpoints were RRs for overall survival (OS) and adverse events (AEs). Results Ten studies with 716 patients were included in this meta‐analysis. Endostar combined with CCRT significantly improved ORR and DCR compared with CCRT. The RRs of ORR and DCR for endostar combined with CCRT versus CCRT were 1.263 (95% CI: 1.137–1.403, p < 0.001) and 1.274 (95% CI: 1.124–1.444, p < 0.001), respectively. Endostar combined with CCRT significantly improved one‐year survival rate compared with CCRT with pooled RR = 1.113 (95% CI: 1.006–1.231, p = 0.038). Endostar combination treatments had similar incidences of main adverse events compared with CCRT ( p > 0.05). Conclusion Endostar combined with CCRT is associated with significantly higher ORR, DCR and survival rate than CCRT with similar incidences of main adverse events in NSCLC.