Open AccessParaneoplastic neuromyelitis optica spectrum disorder associated with malignant melanoma: A case report
Author(s) -
Morimoto Toshiki,
Hayashida Shotaro,
Yamasaki Kei,
Sasahara Yosuke,
Takaki Tsutomu,
Yatera Kazuhiro
Publication year - 2021
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.13965
Subject(s) - medicine , neuromyelitis optica , malignancy , melanoma , spectrum disorder , dermatology , aquaporin 4 , multiple sclerosis , pathology , central nervous system , immunology , cancer research , psychiatry
Neuromyelitis optica spectrum disorders (NMOSDs) are autoimmune demyelinating diseases involving the central nervous system, affecting the spinal cord and optic nerves. There are few reports of paraneoplastic NMOSD associated with malignant melanoma. Here, we report a rare case of anti‐aquaporin 4 (AQP4) antibody‐positive NMOSD associated with malignant melanoma. A 61‐year‐old Japanese woman was diagnosed with malignant melanoma and lung metastasis four years after a diagnosis of anti‐AQP4 antibody‐positive NMOSD. When diagnosing and treating patients with NMOSD, physicians should be aware of the development of malignancy for at least several years.