Open AccessReproducible abscopal effect in a patient with lung cancer who underwent whole‐brain irradiation and atezolizumab administration
Author(s) -
Hotta Takamasa,
Okuno Takae,
Nakao Mika,
Amano Yoshihiro,
Isobe Takeshi,
Tsubata Yukari
Publication year - 2021
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.13875
Subject(s) - abscopal effect , medicine , atezolizumab , immunogenicity , radiation therapy , lung cancer , brain metastasis , oncology , immunotherapy , immune system , cancer , metastasis , immunology , nivolumab
Due to the emergence of immune checkpoint inhibitors, the abscopal effect has gained more attention. We report a case of extracranial abscopal effect after whole‐brain irradiation therapy due to brain metastasis. After the initial abscopal effect was confirmed, a second abscopal effect was confirmed following radiation therapy for bone metastases. This case confirms the reproducibility of the abscopal effect. Moreover, the abscopal effect was not observed in metastatic lesions with low immunogenicity, even in the same patient.