Open AccessProgress in therapeutic strategies based on cancer lipid metabolism
Author(s) -
Diao XiaYao,
Lin Tianxin
Publication year - 2019
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.13146
Subject(s) - lipid metabolism , fatty acid synthesis , cancer cell , fatty acid synthase , cancer , biochemistry , downregulation and upregulation , lipid droplet , fatty acid metabolism , cell growth , fatty acid , enzyme , acetyl coa carboxylase , sphingolipid , metabolism , cancer research , biology , medicine , pyruvate carboxylase , gene
Lipids are widely distributed in cellular organelles and comprise thousands of different types of molecules, including fatty acids, phospholipids, triglycerides, sphingolipids, cholesterol, etc. Normal cells acquire lipids through de novo synthesis and uptake. In order to satisfy the demands of growth and proliferation, cancer cells must rewire their metabolism, especially lipid metabolism. Indeed, lipid synthesis is strongly upregulated in cancers to satisfy the demands of increased membrane biogenesis and even acquire therapeutic resistance. Lipid uptake and storage are also elevated in cancer cells. Targeting lipid metabolism has become a novel anti-cancer strategy.