Open AccessDevelopment of angiosarcoma in a mediastinal non‐seminomatous germ cell tumor that exhibited growing teratoma syndrome during chemotherapy
Author(s) -
Matsuoka Shunichiro,
Koyama Tsutomu,
Takeda Tetsu,
Yamada Kyoko,
Hyogotani Akira,
Hamanaka Kazutoshi,
Sekiguchi Nodoka,
Koizumi Tomonobu
Publication year - 2019
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12901
Subject(s) - medicine , germ cell tumors , immature teratoma , chemotherapy , etoposide , teratoma , angiosarcoma , pathological , seminoma , germ cell , mediastinal mass , bleomycin , pathology , radiology , surgery , biochemistry , gene , chemistry
Herein, we report a case of an angiosarcoma in a mediastinal non‐seminomatous germ cell tumor that exhibited growing teratoma syndrome during chemotherapy. A 26‐year‐old man presented with a giant anterior mediastinal mass, which was diagnosed as a non‐seminomatous germ cell tumor. The patient was administered three cycles of chemotherapy (bleomycin, etoposide, and cisplatin), but the mass grew despite normalization of tumor markers. Massive bleeding during thoracic surgery resulted in incomplete resection, and the mass was clinically and pathologically diagnosed as growing teratoma syndrome (only mature teratoma). The residual mass continued to grow, and complete resection was subsequently achieved after a detailed analysis of its vascular anatomy using angiography. The final pathological findings revealed angiosarcoma, which indicated a rare somatic type of mediastinal non‐seminomatous germ cell tumor.