Open AccessALK ‐rearranged lung cancer with intradural extramedullary spinal cord metastases responding to ceritinib treatment: A case report
Author(s) -
Xu Yan,
Zhong Wei,
Chen Minjiang,
Zhao Jing,
Wang Mengzhao
Publication year - 2018
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12778
Subject(s) - medicine , crizotinib , ceritinib , lung cancer , spinal cord , magnetic resonance imaging , radiology , pathology , psychiatry , malignant pleural effusion
Intradural extramedullary spinal cord metastases in lung cancer are rarely reported, but are a disastrous event because of severe clinical symptoms and poor prognosis. Herein, we report a case of a lung cancer patient with ALK rearrangement who experienced brain, leptomeningeal, and intradural extramedullary spinal cord metastases after developing resistance to crizotinib. After ceritinib therapy, his clinical symptoms improved and magnetic resonance imaging revealed that the intradural extramedullary lesions had reduced.