Open AccessResearch progress on the relationship between zinc deficiency, related micro RNA s, and esophageal carcinoma
Author(s) -
Liu CongMin,
Liang Di,
Jin Jing,
Li DaoJuan,
Zhang YaChen,
Gao ZhaoYu,
He YuTong
Publication year - 2017
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12493
Subject(s) - microrna , medicine , cancer research , incidence (geometry) , esophageal cancer , cancer , gene , gastrointestinal tract , bioinformatics , oncology , genetics , biology , physics , optics
Esophageal cancer (EC) is a common malignant tumor of the gastrointestinal tract with a high incidence in C hina. Zinc (Zn) deficiency is a key risk factor for the occurrence and development of EC and affects progression by regulating micro RNA (miRNA, miR) expression. In addition, the dysregulation of mi RNA s is accompanied by the dysregulation of their target genes in EC. In this paper, we review the potential molecular mechanisms between Zn deficiency and EC with the aim of providing new strategies and methods for early diagnosis, targeted therapy, and prognostic evaluation.