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Background  The prognostic values of  p reoperative  n eutrophil/ l ymphocyte  r atio ( NLR ), monocyte/lymphocyte ratio ( MLR ), and platelet/lymphocyte ratio ( PLR ) in non‐small cell lung cancer ( NSCLC ) have been previously described. This study assessed the prognostic values of other pretreatment  complete blood cell  parameters in  C hinese patients with curatively resected  NSCLC .    Methods  A total of 1466 consecutive  NSCLC  patients who received curative surgery from  J anuary 1, 2005 to  D ecember 31, 2009 with complete data from pretreatment blood tests were enrolled in this retrospective study. Correlations between each blood test parameter and overall survival were examined by  K aplan– M eier method or  C ox proportional hazards regression, followed by a stratification analysis of significant variables.    Results  Optimal cut‐off values of 0.55 for  n eutrophil/ w hite  b lood  c ell  r atio ( NWR ), 0.28 for  l ymphocyte/ w hite  b lood  c ell  r atio ( LWR ), 0.09 for  m onocyte/ w hite  b lood  c ell  r atio ( MWR ), 2.06 for  NLR , 0.35 for  MLR , 204.00 for  PLR , and 38.25 for  p latelet/ w hite  b lood  c ell  r atio ( PWR ) were identified using  X ‐tile software. Univariate analysis suggested that  NWR  ≥ 0.55,  LWR  < 0.28,  MWR  ≥ 0.09,  NLR  ≥ 2.06,  MLR  ≥ 0.35, and  PLR  ≥ 204.00 predicted a poor prognosis in  NSCLC  patients. However, only  NWR  and  MLR  were identified as independent significant prognostic factors in multivariable analysis, especially in tumor node metastasis stage  I  and  I/II/III NSCLC s.    Conclusion  Pretreatment  NWR ,  MWR ,  LWR ,  NLR ,  MLR , and  PLR  values are associated with poor overall survival for patients with curatively resected  NSCLC .  NWR  and  MLR  are independent prognostic factors in curatively resected  NSCLC .

thoracic cancer

Elevated pretreatment  n eutrophil/ w hite  b lood  c ell  r atio and  m onocyte/ l ymphocyte  r atio predict poor survival in patients with curatively resected non‐small cell lung cancer:  R esults from a large cohort