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Background  Phosphatase and tensin homolog (  PTEN  ), regarded as a tumor suppressor gene, may act as a prognostic biomarker in human cancers.    Methods  All eligible studies from  MEDLINE ,  Embase ,  CENTRAL , and the  C hinese  B io M edical  L iterature  D atabase to  O ctober 2016 were incorporated. Two reviewers independently screened the literature according to inclusion and exclusion criteria, extracted the data, assessed the methodological quality of the included studies, and conducted meta‐analysis.    Results  A total of 2486 patients from 19 studies were included.  PTEN  expression was significantly correlated with gender, smoking history, histology (adenocarcinoma [ ADC ] vs. squamous cell carcinoma), tumor node metastasis stage ( I–II  vs.  III–IV ),  N  status ( N 0 vs.  N 1– N 3), and distant metastasis ( M 0 vs.  M 1).  L oss of  PTEN  expression was associated with poorer overall survival, but had no significant association with  disease‐free survival . Subgroup analysis showed that negative  PTEN  expression was associated with a poorer outcome in  A sian and  ADC  patients, but not in  W estern or squamous cell carcinoma patients.    Conclusion  Loss of  PTEN  might play an unfavorable prognostic role for overall survival of  non‐small cell lung cancer  patients, especially  A sian or  ADC  patients.

thoracic cancer

Loss of phosphatase and tensin homolog expression correlates with clinicopathological features of non‐small cell lung cancer patients and its impact on survival:  A  systematic review and meta‐analysis