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Background  Esophageal cancer has a high mortality rate, particularly in Asia, and there are obvious racial differences in regard to incidence. The purpose of our study was to assess the genetic susceptibility of functional single nucleotide polymorphisms in flap endonuclease‐1 ( FEN 1) in esophageal squamous cell carcinoma  ESCC .    Methods  Clinical blood samples of 629  ESCC  cases and 686 control samples were collected. The ligation detection reaction method was used to determine  FEN  1  rs174538 G>A genotypes.    Results  A significantly decreased risk of  ESCC  was associated with  FEN  1  rs174538  GA  genotypes among patients under 63 years old.    Conclusions  Our results suggest that functional polymorphism  FEN  1  rs174538 G>A might affect personal susceptibility to  ESCC . This result provides a solid theoretical foundation for further clinical study using larger sample sizes.

Flap endonuclease‐1 rs174538 G>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population