Open AccessTopoisomerase I expression is associated with prognosis in postoperative non‐small cell lung cancer patients
Author(s) -
Lu Baohua,
Zhang Hongmei,
Zhang Tongmei,
Cai Yiran,
Hu Ying,
Zheng Hua,
Li Baolan
Publication year - 2016
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12359
Subject(s) - medicine , thymidylate synthase , topoisomerase , lung cancer , immunohistochemistry , pathological , stage (stratigraphy) , cancer , oncology , carcinoma , metastasis , cell , clinical significance , pathology , cancer research , enzyme , biology , fluorouracil , paleontology , biochemistry , genetics
Background Biomarkers may help to improve non‐small cell lung cancer ( NSCLC ) prognosis. However, the prognostic effect of topoisomerase I (Topo I) on NSCLC is unknown. We evaluated the clinicopathologic and prognostic significance of tumor Topo I and thymidylate synthase ( TS ) protein expression in postoperative NSCLC patients. Methods One hundred and fifteen patients with postoperative NSCLC were enrolled. Topo I and TS protein were detected in removed tumors by i mmunohistochemistry. The correlations between Topo I/TS protein expression and clinicopathologic characters and outcomes of patients were analyzed. Results Increased expression of Topo I was found in 57 (49.6%) tumors. The largest diameter of the tumor was significantly different between patients with high and low Topo I expression ( P = 0.035). TS staining showed that 35 (30.4%) carcinomas were TS positive. The level of TS expression was correlated with tumor differentiation ( P = 0.037). Patients with low Topo I expression had significantly longer overall survival ( OS ) than those with high expression ( P = 0.004). The correlation between Topo I expression and OS was demonstrated among patients with squamous cell carcinoma ( P = 0.030) and patients in pathological tumor node metastasis stage I ( P = 0.027). Topo I expression was positively correlated with TS expression in tumor tissue (R = 0.251, P = 0.007). Conclusions Low Topo I expression is an independent favorable prognostic factor for longer OS in postoperative NSCLC patients, especially in squamous cell carcinoma. There is a correlation between the expression of TS and Topo I in removed tumor tissue.