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Gardner's syndrome is a hereditary disorder inherited as an autosomal dominant with high penetrance and variable expression that is caused by a mutation of the adenomatous polyposis coli gene. It is characterized by gastrointestinal polyps associated with multiple osteomas, dental anomalies, and skin and soft tissue tumors. We present a case of 30‐year‐old female patient with  G ardner's syndrome who presented with a giant mediastinal thymolipoma. The tumor was completely excised through a bilateral posterolateral thoracotomy. There was no recurrence after 20 months of follow‐up. We therefore suggest that physicians who regularly treat patients with  G ardner's syndrome carefully examine for thoracic manifestations.

Giant mediastinal thymolipoma in a patient with G ardner's syndrome