Open AccessMyelomatous pleural effusion involvement in 23 patients with multiple myeloma: A single‐center clinical analysis
Author(s) -
Zhong Yuping,
Zhang Jiajia,
Wang Huan
Publication year - 2015
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12220
Subject(s) - medicine , multiple myeloma , pleural effusion , single center , bortezomib , effusion , gastroenterology , progressive disease , surgery , disease , radiology
We investigated the treatment and prognosis of pleural effusion ( PE ) in multiple myeloma ( MM ) patients. From J une 2005 to D ecember 2013, 296 MM patients participated in this study. There were 23 PE patients, including 11 men and 12 women, with a median age of 56.8 years (range 37–68 years). A diagnosis of PE was based on physical examination, chest X ‐ray or computed tomography, and pleural fluid analysis. All patients demonstrated myeloma cells in the pleural fluid, and six patients were positive for PE M protein. PE patients received bortezomib combined with other drugs. Only one patient demonstrated a complete response; 10 patients showed partial responses, and 12 patients developed progressive disease and died. MM linked with myelomatous PE is associated with a poor prognosis. Myelomatous PE is likely a late manifestation of the natural history of MM or an expression of the aggressive behavior of the disease.