Open AccessMetastases of basal‐like breast invasive ductal carcinoma to the endometrium: A case report and review of the literature
Author(s) -
Huo Zhijun,
Gao Yongsheng,
Zuo Wenshu,
Zheng Gang,
Kong Ronghua
Publication year - 2015
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12195
Subject(s) - medicine , cytokeratin , endometrium , progesterone receptor , pathology , breast cancer , metastasis , estrogen receptor , immunohistochemistry , epidermal growth factor receptor , epidermal growth factor , hormone receptor , invasive lobular carcinoma , carcinoma , ca15 3 , oncology , cancer , receptor , invasive ductal carcinoma
We present a case of single endometrial metastasis from breast invasive ductal cancer. This case was unique because the immunohistochemical staining was negative for human epidermal growth factor receptor 2/neu and estrogen and progesterone receptors, and positive for cytokeratin 5/6 and epidermal growth factor receptor in the primary and metastatic tumor cells. No gross evidence of tumor was observed in other sites. We identified 12 cases of metastases to the endometrium from breast carcinoma from series and case reports in the literature between 1985 and 2014. This review indicated that hormone receptor‐positive invasive lobular breast cancer cells are more likely to metastasize to the endometrium than other cell types in patients over 50 years of age.