Open AccessInfluence of different image‐guided tracking methods upon the local efficacy of C yber K nife treatment in lung tumors
Author(s) -
Guo Yihang,
Zhuang Hongqing,
Zhao Lujun,
Yuan Zhiyong,
Wang Ping
Publication year - 2015
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12174
Subject(s) - medicine , cyberknife , lung cancer , lung , radiosurgery , treatment of lung cancer , lung tumor , tracking (education) , radiation therapy , nuclear medicine , radiology , oncology , psychology , pedagogy
Background The aim of this study was to explore the influence of image‐guided tumor localization modality ( S ynchrony tracking vs. X sight spine‐based localization) on the local efficacy of C yber K nife treatment in lung cancer and lung metastases. Methods Retrospective analysis of 64 patients with pulmonary metastases and primary tumor cases (72 targets) treated with stereotactic body radiotherapy using C yber K nife was conducted. Synchrony respiratory tracking was used to treat 45 targets, and the remaining 27 targets were treated using X sight spine (with an extended margin to account for positional uncertainty). The median (80%) isodose line (70–94%) covered the planning target volume at a total dose of 6000 cGy delivered in three fractions. Local efficacy was evaluated by R esponse E valuation C riteria in S olid T umors, accompanied by the follow‐up of local recurrence cases and analysis of tracking methods. Results Short‐term local control was superior for targets tracked with S ynchrony than for targets localized with X sight spine. There was no statistical difference for targets in the upper lung, but for targets in the lower lung S ynchrony tracking was better. Small targets (less than 15 mL) were better controlled when S ynchrony was used, but there was no difference for treatment volumes larger than 15 mL. Treatment failures were more likely in the lower lung and for small tumors localized with X sight spine. Conclusions The local efficacy of C yber K nife treatment in lung cancer and lung metastases was influenced by image‐guided localization method, target location within the lung, and tumor volume.