Open AccessSurgical results of resectable small cell lung cancer
Author(s) -
Kawano Daigo,
Okamoto Tatsuro,
Fujishita Takatoshi,
Suzuki Yuzo,
Kitahara Hirokazu,
Shimamatsu Shinichiro,
Maehara Yoshihiko
Publication year - 2015
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12154
Subject(s) - medicine , pneumonectomy , stage (stratigraphy) , hazard ratio , surgery , multivariate analysis , radiation therapy , lung cancer , proportional hazards model , chemotherapy , oncology , confidence interval , paleontology , biology
Background The standard of care for patients with small cell lung cancer ( SCLC ) is chemotherapy and radiotherapy, even for patients with limited disease. To define the role of surgical resection in patients with limited SCLC , we investigated the outcomes of patients diagnosed with limited‐stage disease ( LD ) SCLC . Methods The records of 57 LD SCLC patients who underwent surgical resection from A pril 1974 to M arch 2012 were retrospectively analyzed. Results There were six women and 51 men, with a median age of 63.5 years. The overall five‐year survival rate was 28.6% (median, 18.2 months). The p‐stage II and III patients had a significantly worse survival than the p‐stage I patients (13.4% vs. 43.4%, P = 0.0036). However, the c‐stage was not found to correlate with survival. Patients who underwent pneumonectomy had a significantly worse outcome than those who underwent other surgical procedures (0.0% vs. 32.0%, P = 0.0002). In a multivariate Cox proportional hazards analysis, p‐stage II or III (hazard ratio [HR] 3.040 P = 0.0017) and pneumonectomy (HR 6.177, P = 0.00159) were significant independent predictors of an adverse survival outcome. Conclusions Surgical treatment can be considered in SCLC patients with pathologically proven N0 status, although pneumonectomy should be avoided.