Open AccessGranulocyte‐colony stimulating factor ( G ‐ CSF ) producing malignant pleural mesothelioma: Report of a case
Author(s) -
Fujiwara Ayako,
Higashiyama Masahiko,
Kanou Takashi,
Okami Jiro,
Tokunaga Toshiteru,
Tomita Yasuhiko,
Kodama Ken
Publication year - 2015
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12140
Subject(s) - medicine , granulocyte colony stimulating factor , immunohistochemistry , chest pain , monoclonal antibody , respiratory system , granulocyte , pathology , gastroenterology , surgery , antibody , chemotherapy , immunology
This report presents a case of malignant pleural mesothelioma ( MPM ) producing granulocyte colony‐stimulating factor ( G ‐ CSF) that was treated by tumor resection. A 76‐year‐old male presented with a huge right‐side chest wall tumor, along with a slight fever and chest wall pain. Laboratory findings showed an increased white blood cell count (64600 cells/μL) and C‐reactive protein level (20.57 mg/dL). The patient underwent surgical removal of the tumor along with tissue from the chest wall and histopathological analysis led to a diagnosis of sarcomatous type of MPM . Immunohistochemical findings for both anti‐human G ‐ CSF and interleukin‐6 monoclonal antibodies were positive. Although the general condition of the patient quickly improved after surgery, local recurrence occurred two months later and he died of respiratory failure seven months after the operation, though surgery provided symptom relief. G ‐ CSF ‐producing MPMs usually show a poor prognosis, though less‐invasive surgery may be considered for relief of symptoms.