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In the present study, we analysed how geographical distribution of the fungal pathogen  Cryptococcus gattii  VGI in Europe and Mediterranean area has evolved in the last four decades based on the climatic changes, and we tried to predict the scenario for the next decade. Niche modelling by Maxent analysis showed that recent climate changes have significantly affected the distribution of the fungus revealing a gradual expansion of the fundamental niche from 1980 to 2009 followed by an impressive increase in the last decade (2010–2019) during which the environmental surface suitable for the fungal survival was more than doubled. In the next decade, our model predicted an increase in the area of distribution of  C .  gattii  VGI from the coasts of the Mediterranean basin towards the more internal sub‐continental areas. On the basis of these predictions, an increase of cases of cryptococcosis due to  C .  gattii  VGI is expected in the next decade and a constant monitoring of the epidemiology of this fungal pathogen represents a crucial strategy to detect the onset of future outbreaks.

Global warming impact on the expansion of fundamental niche of Cryptococcus gattii VGI in Europe