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Mesenchymal stem cells transplantation for systemic lupus erythematosus
Author(s) -
Liang Jun,
Sun Lingyun
Publication year - 2015
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12531
Subject(s) - mesenchymal stem cell , medicine , stem cell , immunology , stem cell transplantation for articular cartilage repair , haematopoiesis , bone marrow , clinical uses of mesenchymal stem cells , adult stem cell , immune system , transplantation , cancer research , cellular differentiation , pathology , microbiology and biotechnology , biology , biochemistry , gene
Mesenchymal stem cells are a rare subset of stem cells residing in the bone marrow where they closely interact with hematopoietic stem cells and support their growth and differentiation. They can suppress proliferation or functions of many immune cells such as T cells, B cells, natural killer cells and dendritic cells. Recently, a substantial progress has been made in the field of mesenchymal stem cell transplantation. Experimental and clinical data suggest that this therapy has been a promising strategy for severe and refractory systemic lupus erythematosus.