Open Access正常蛋白尿的2型糖尿病患者肾功能不全状况的研究:基于中国人群的多中心研究
Author(s) -
Jia Xiaomeng,
Zang Li,
Pang Ping,
Jiang Lina,
Du Jin,
Gu Weijun,
Ba Jianming,
Mu Yiming,
Lyu Zhaohui
Publication year - 2022
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.13230
Subject(s) - medicine , albuminuria , microalbuminuria , renal function , diabetes mellitus , kidney disease , urology , population , creatinine , endocrinology , type 2 diabetes mellitus , environmental health
Abstract Background Patients with normoalbuminuria and a reduced estimated glomerular filtration rate (eGFR) account for a considerable proportion of type 2 diabetes patients. The aim of this research was to investigate the epidemiological and clinical characteristics of normoalbuminuric kidney disease in a Chinese population. Methods We included 8131 diabetic patients from a multicenter prospective study in China. Based on eGFR and urinary albumin‐to‐creatinine ratio (UACR), participants were stratified into four groups—normal albuminuria, albuminuria, normoalbuminuria with eGFR < 60 mL/min/1.73 m 2 , and albuminuria with eGFR < 60 mL/min/1.73 m 2 . Clinical parameters and characteristics of patients with normoalbuminuria and eGFR < 60 mL/min/1.73 m 2 were retrospectively analyzed. Results A total of 1060 out of 8131 individuals with diabetes had decreased eGFR (<60 mL/min/1.73 m 2 ). Normoalbuminuria accounted for 63.3% of participants with eGFR < 60 mL/min/1.73 m 2 , and microalbuminuria and macroalbuminuria accounted for 30.1% and 6.3%, respectively. Patients with normoalbuminuria and reduced eGFR were more frequently male, older, and had higher levels of triglycerides than patients with normal albuminuria and eGFR. We also detected a correlation between lower extremity arterial disease, newly diagnosed diabetes, and normoalbuminuria‐reduced eGFR. Compared with participants with both albuminuria and eGFR decline, those with normoalbuminuria had better metabolic indicators, including systolic blood pressure and glycosylated hemoglobin, and shorter diabetes duration. Even in the normal range, UACR has a significant correlation with the risk of eGFR insufficiency. Conclusions Normoalbuminuric renal insufficiency, characterized by male sex, older age, a higher level of triglyceride levels, and a higher risk of lower extremity arterial disease, accounted for a dominant proportion of diabetic patients with eGFR decline.