Open AccessTranscriptome dynamics and metabolite analysis revealed the candidate genes and regulatory mechanism of ganoderic acid biosynthesis during liquid superficial‐static culture of Ganoderma lucidum
Author(s) -
Wang Qiong,
Xu Mengmeng,
Zhao Liting,
Wang Feng,
Li Youran,
Shi Guiyang,
Ding Zhongyang
Publication year - 2021
Publication title -
microbial biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.287
H-Index - 74
ISSN - 1751-7915
DOI - 10.1111/1751-7915.13670
Subject(s) - transcriptome , lanosterol , biosynthesis , ergosterol , gene , metabolite , ganoderma , biochemistry , biology , secondary metabolite , chemistry , ganoderma lucidum , gene expression , sterol , food science , cholesterol
Liquid superficial‐static culture was a better method to produce GA. Transcriptome dynamics analysis revealed CYP5150L8 was the key gene regulating lanosterol flux into GA biosynthesis. Other sixteen CYP450s genes were significantly higher‐expressed during the culture time in LSSC and could be potential candidate genes associated with the biosynthesis of different GAs.