Open AccessMulti‐modular engineering of Saccharomyces cerevisiae for high‐titre production of tyrosol and salidroside
Author(s) -
Liu Huayi,
Tian Yujuan,
Zhou Yi,
Kan Yeyi,
Wu Tingting,
Xiao Wenhai,
Luo Yunzi
Publication year - 2021
Publication title -
microbial biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.287
H-Index - 74
ISSN - 1751-7915
DOI - 10.1111/1751-7915.13667
Subject(s) - tyrosol , salidroside , metabolic engineering , biochemistry , saccharomyces cerevisiae , chemistry , yeast , phenols , chromatography , enzyme
In this work, Liu et al. used metabolic engineering strategies to construct S. cerevisiae strains for high‐level production of tyrosol and salidroside from glucose. Finally, titers of 9.90 ± 0.06 g l −1 of tyrosol and 26.55 ± 0.43 g l −1 of salidroside were achieved in 5 l bioreactors, both are the highest titers reported to date.