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Bile reflux is an independent risk factor for precancerous gastric lesions and gastric cancer: An observational cross‐sectional study
Author(s) -
Zhang Lu Yao,
Zhang Jian,
Li Dan,
Liu Yuan,
Zhang Dong Ling,
Liu Cai Fang,
Wang Na,
Wu Si Ran,
Lu Wen Quan,
Guo Jing Zhi,
Shi Yong Quan
Publication year - 2021
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12986
Subject(s) - medicine , gastroenterology , helicobacter pylori , odds ratio , bile reflux , risk factor , cancer , cross sectional study , intraepithelial neoplasia , intestinal metaplasia , dysplasia , reflux , atrophic gastritis , gastritis , pathology , disease , prostate cancer
Objective To identify whether bile reflux on endoscopy and other related variables are risk factors for precancerous gastric lesions and gastric cancer (GC). Methods A multicenter, cross‐sectional and observational study was conducted in five centers in China from June to October 2019, 1162 patients were recruited and divided into the chronic gastritis (CG), the precancerous lesion (low‐grade intraepithelial neoplasia and intestinal metaplasia), and GC groups (including high‐grade intraepithelial neoplasia). All participants underwent detailed interviews, endoscopy and biopsy, and completed questionnaires. Odds ratio and 95% confidence interval were calculated with multivariate logistic regression models with or without adjustment for Helicobacter pylori infection. Results We recruited 668 patients with CG, 411 with precancerous lesions and 83 with GC. By comparing the CG and precancerous lesion groups, independent risk factors for cancerous gastric lesions were the grade of bile reflux, patient's age, dietary habits and family history of GC. Similar results were obtained when comparing the CG and GC groups. In addition, bile reflux was confirmed as an independent risk factor for progression from precancerous lesions to cancer. Conclusions Bile reflux on endoscopy as well as age, dietary habits and a family history of GC were independent risk factors for the development of precancerous gastric lesions and GC.