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Objective  To investigate whether less invasive methods of autopsy would be acceptable to bereaved parents and likely to increase uptake.    Design  Mixed methods study.    Setting  Bereaved parents recruited prospectively across seven hospitals in England and retrospectively through four parent support organisations.    Sample  Eight hundred and fifty‐nine surveys and 20 interviews with bereaved parents.    Methods  Cross‐sectional survey and qualitative semi‐structured telephone interviews.    Main outcome measures  Likely uptake, preferences, factors impacting decision‐making, views on different autopsy methods.    Results  Overall, 90.5% of participants indicated that they would consent to some form of less invasive autopsy [either minimally invasive autopsy ( MIA ), non‐invasive autopsy ( NIA ) or both]; 53.8% would consent to standard autopsy, 74.3% to  MIA  and 77.3% to  NIA . Regarding parental preferences, 45.5% preferred  MIA , 30.8% preferred  NIA  and 14.3% preferred standard autopsy. Participants who indicated they would decline standard autopsy but would consent to a less invasive option were significantly more likely to have a lower educational level (odds ratio 0.49; 95%  CI  0.35–0.70;  P  = 0.000062). Qualitative findings suggest that parents value  NIA  because of the lack of any incision and  MIA  is considered a good compromise as it enables tissue sampling while easing the parental burden associated with consenting to standard autopsy.    Conclusion  Less invasive methods of autopsy are acceptable alternatives for bereaved parents, and if offered, are likely to increase uptake and improve parental experience. Further health economic, validation and implementation studies are now required to assess the viability of offering these in routine widespread clinical care.    Tweetable abstract  Mixed methods  UK  study finds less invasive methods of autopsy are acceptable alternatives for bereaved parents, and if offered, are likely to increase uptake and improve parental experience.

Availability of less invasive prenatal, perinatal and paediatric autopsy will improve uptake rates: a mixed‐methods study with bereaved parents