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Upcoming diagnostic biomarkers with promising prospects in neurological disorders
Author(s) -
Ahmad Wasim,
Ali Abuzer,
Ali Amena,
Khan Sana,
Khan Saba,
Husain Ibraheem
Publication year - 2020
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/1440-1681.13216
Subject(s) - context (archaeology) , intensive care medicine , biomarker , medicine , neuroscience , bioinformatics , psychology , biology , paleontology , biochemistry
Abstract An exponential increase in the prevalence of neurological disorders requires substantial steps to be taken for their prevention and treatment. Neurodiagnostic biomarkers are gaining momentum presently in order to enhance the diagnostic accuracy of neurodegenerative disorders, to precisely assess their advancement and to monitor the efficiency of therapeutic interventions. Therefore, the primary focus of the present review is the recent development in this field of neurodiagnostic biomarkers, and the current state of biomarker exploration in the context of various neurodegenerative diseases. This review encompasses an updated and detailed account of specific (β‐Amyloid, Tau and Phospho‐tau 181, Tar‐DNA binding protein‐43, Progranulin, a‐synuclein, Clusterin, etc) and non‐specific (genetic, synaptic, inflammatory and coagulation) neurodiagnostic biomarkers and the recent advances in this growing field. This comprehensive review also suggests the utilization of neurodiagnostic markers in network approaches and personalized medication that will eventually improvise the existing diagnostic and therapeutic complexities of neurodiagnostic biomarkers.