English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the zaia usage as premium feature

ZAIA

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the access of premium content as premium feature

Premium Content

Zendy Tools

Zendy Open

Summary  The present study aimed to investigate the possible influence of several inhibitors and blockers on the vascular effect produced by the acute  in vitro  application of rosuvastatin to phenylephrine‐precontracted aortic rings from rats with a semi‐solid, cafeteria‐style ( CAF ) diet. It also aimed to examine the effects of rosuvastatin on the expression of endothelial nitric oxide synthase ( eNOS ), inducible nitric oxide synthase, constitutive cyclooxygenase, and inducible cyclooxygenase in aortic rings from rats with a  CAF  diet. From comparisons of the effect on phenylephrine‐precontracted aortic rings extracted from rats with two different diets (a standard and a  CAF  diet), it was found that 10 −9 –10 −5 ‐mol/L rosuvastatin produced lower concentration‐dependent vasorelaxation on rings from the  CAF  diet group. The vasorelaxant effect was unaffected by the vehicle, but it was significantly attenuated by 10 −5 ‐mol/L   N  G  ‐nitro‐ l ‐arginine methyl ester, 10 −2 ‐mol/L tetraethylammonium, 10 −3 ‐mol/L 4‐aminopyridine, 10 −7 ‐mol/L apamin plus 10 −7 ‐mol/L charybdotoxin, 10 −5 ‐mol/L indomethacin, or 10 −5 ‐mol/L cycloheximide. Moreover, in aortic rings from rats with a  CAF  diet, rosuvastatin enhanced the expression of  eNOS , inducible nitric oxide synthase, constitutive cyclooxygenase, and inducible cyclooxygenase. The acute  in vitro  application of rosuvastatin to phenylephrine‐precontracted aortic rings from rats with a  CAF  diet had a vasorelaxant effect. Overall, the present results suggest that the stimulation of  eNOS , the opening of Ca 2+ ‐activated and voltage‐activated K +  channels, the stimulation of prostaglandin synthesis and enhanced protein levels of  eNOS , inducible nitric oxide synthase, constitutive cyclooxygenase, and inducible cyclooxygenase are involved in this relaxant effect.

clinical and experimental pharmacology and physiology

Pharmacological characterization of mechanisms involved in the vasorelaxation produced by rosuvastatin in aortic rings from rats with a cafeteria‐style diet