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Alpinia intermedia , a perennial plant that belongs to the Zingiberaceae family, has been used in folk medicine for a long time in the southern region of Japan. Because skin care is an effective approach that enables patients to manage their atopic dermatitis ( AD ), various herbal ingredients with few adverse effects have been evaluated for use in  AD  patients in recent years. In this study, we examined whether distilled extracts obtained from  A. intermedia  were beneficial for  AD ‐like skin conditions in  NC /Tnd mice. Topical application with the  A. intermedia  extracts significantly reduced the severity of  AD , transepidermal water loss and scratching behavior in the mice. Supplementation of the extracts to cell cultures suppressed the expression of  Tslp   mRNA  in  PAM 212 keratinocytes, degranulation in bone marrow‐derived cultured mast cells ( BMCMC ), and neurite outgrowth in  PC 12 cells and dorsal root ganglia. In addition, the component analysis revealed that β‐pinene was a major constituent of the  A. intermedia  extracts. The inhibitory effects of β‐pinene both  in vivo  and  in vitro  were also demonstrated. These results indicate that topical application with the  A. intermedia  extract to the skin of  NC /Tnd mice improved the condition of the skin by suppressing multiple inflammatory responses. The extracts may become novel skin‐care remedies for  AD  patients.

Amelioration of atopic‐like skin conditions in NC /Tnd mice by topical application with distilled Alpinia intermedia Gagnep extracts