Premium
Successful treatment by negative‐pressure wound therapy for ulcer located on diffuse plexiform neurofibroma
Author(s) -
Sekiyama Hiroko,
Nobeyama Yoshimasa,
Nakagawa Hidemi
Publication year - 2017
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13983
Subject(s) - medicine , hematoma , surgery , neurofibromatosis , lesion , physical examination , nodule (geology) , neurofibroma , negative pressure wound therapy , radiology , pathology , paleontology , biology , alternative medicine
Dear Editor, Hematoma is common within diffuse plexiform neurofibroma (dNF) and can lead to skin ulceration. We encountered two neurofibromatosis type 1 (NF1) patients whose ulcers due to hematoma in dNF were successfully treated by negativepressure wound therapy (NPWT). Case 1 was a 48-year-old Japanese male NF1 patient who was referred to us with a few-day history of an ulcer on a dNF on the right buttock (Fig. 1a). The patient had noticed swelling of the dNF on the buttock without any apparent cause and was referred to another hospital where the nodule was incised, and the hematoma was removed. Physical examination on the first visit to us revealed an ulcer with an opening size of 4.0 cm 9 1.5 cm and a depth of 7.0 cm located on the dNF (Fig. 1a). Computed tomography revealed a tissue defect in the area of heterogeneous density (Fig. S1a). We performed NPWT to treat the ulcer using V.A.C. (Acelity L.P., San Antonio, TX, USA). After therapy with negative pressure at 75 mmHg for 14 days, the ulcer was markedly improved (opening size, 2.0 cm 9 0.8 cm; depth, 2.5 cm) (Fig. 1b). Case 2 was a 43-year-old Japanese female NF1 patient who was referred to us with a 2-day history of swelling of a