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In this paper, a comprehensive analysis of strength-based optimum signal detection model has been presented for concentration-encoded molecular communication (CEMC) with spike (i.e., impulsive) transmission based on amplitude-shift keying (ASK) and on-off keying (OOK) modulations. Strength-based optimum signal detection problem in diffusion-based CEMC system has been investigated in detail in the presence of both diffusion noise and intersymbol interference (ISI). The receiver for optimum signal detection has been developed theoretically and explained with both analytical and simulation results of binary signal detection. Results show that the receiver thus developed can detect CEMC symbols effectively; however, the performance is influenced by three main factors, namely, communication range, transmission data rate, and receiver memory. For both ASK and OOK receivers, exact and approximate detection performances have been derived analytically depending on the probabilistic nature of molecular availability and the relationship between mean and variance of signal strengths. Correspondingly, bit error rate (BER) performance of the optimum receiver in a single CEMC link is further evaluated under various scenarios through extensive simulation experiments.

A Comprehensive Analysis of Strength-Based Optimum Signal Detection in Concentration-Encoded Molecular Communication With Spike Transmission