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Optical coherence tomography (OCT) is a non-invasive and label-free optical imaging system offering real-time visualization of morphological structures. The high costs associated with most existing commercial OCT systems have restricted their widespread availability, particularly in low-resource environments. Therefore, miniaturizing OCT devices holds the potential not only to reduce size but also to lower costs, opening up new markets for this technology. In this study, we developed single board computer-based compact and portable OCT system (SBC-OCT), which was fabricated by 3D printer. The total size of the developed SBC-OCT system is 230 &#x00D7; 230 &#x00D7; 330 mm 3 . To counter the thermal-induced alignment distortion of 3D printed spectrometer during system operation, we developed an automatic signal compensation method applied temperature-insensitive spectrometer using an area-scan camera with no hardware modifications, no additional components, and minimal computational load. By comparing with conventional line-scan camera-based OCT during 90 min monitoring, the temperature variance robustness of developed SBC-OCT effectively verified and successfully restored distorted images to their original quality. In addition, the applicability of our developed SBC-OCT system was demonstrated through cornea, retina, and fingerprint anti-spoofing imaging. The reduction in size, weight, and cost of SBC-OCT makes it highly relevant across medical, industrial, and security applications, demonstrating its potential for wide-ranging usage.

Development of single board computer-based temperature-insensitive compact optical coherence tomography for versatile applications