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Objective:  This study aims to explore the potential of organic electrolytic photocapacitors (OEPCs), an innovative photovoltaic device, in mediating the activation of native voltage-gated Cav1.2 channels ( I  Ca,L ) in Guinea pig ventricular cardiomyocytes.  Methods:  Whole-cell patch-clamp recordings were employed to examine light-triggered OEPC mediated  I  Ca,L  activation, integrating the channel&#x0027;s kinetic properties into a multicompartment cell model to take intracellular ion concentrations into account. A multidomain model was additionally incorporated to evaluate effects of OEPC-mediated stimulation. The final model combines external stimulation, multicompartmental cell simulation, and a patch-clamp amplifier equivalent circuit to assess the impact on achievable intracellular voltage changes.  Results:  Light pulses activated  I  Ca,L , with amplitudes similar to voltage-clamp activation and high sensitivity to the L-type Ca 2&#x002B;  channel blocker, nifedipine. Light-triggered  I  Ca,L  inactivation exhibited kinetic parameters comparable to voltage-induced inactivation.  Conclusion:  OEPC-mediated activation of  I  Ca,L  demonstrates their potential for nongenetic optical modulation of cellular physiology potentially paving the way for the development of innovative therapies in cardiovascular health. The integrated model proves the light-mediated activation of  I  Ca,L  and advances the understanding of the interplay between the patch-clamp amplifier and external stimulation devices.  Significance:  Treating cardiac conduction disorders by minimal-invasive means without genetic modifications could advance therapeutic approaches increasing patients&#x2019; quality of life compared with conventional methods employing electronic devices.

ieee transactions on biomedical engineering

Shedding Light on Cardiac Excitation: In Vitro and In Silico Analysis of Native Ca 2&#x002B;  Channel Activation in Guinea Pig Cardiomyocytes Using Organic Photovoltaic Devices