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The increasing sophistication of malware threats has led to growing concerns in the anti-malware community, as malware poses a significant danger to online users despite the availability of numerous defense solutions. The aim of this study is to comprehensively review malware evolution and current attack trends in order to identify effective defense mechanisms. This study reviewed the most recent journal articles, conference proceedings, reports, and online resources published over the last five years. We extensively reviewed the malware landscape from 1970 to the present, and analyzed its types, operational mechanisms, attack vectors, and vulnerabilities. Furthermore, we explored different defensive strategies developed in response to these evolving threats. Our findings highlight the increasing sophistication of malware attack trends, including a surge in cryptojacking, attacks on mobile devices, Internet of Things devices, ransomware, advanced persistent threats, supply chain attacks, fileless malware, cloud-based attacks, exploitation of remote employees, and attack trends on edge networks. Defense strategies have also evolved in parallel, emphasizing multi-layered security measures to counter these dynamic threats. This study highlights the critical need for robust, multi-layered security measures to combat dynamic malware. Despite these advancements, some open challenges and significant research gaps remain, which require further innovation. This review serves as a valuable guide for cybersecurity professionals by identifying the key trends, challenges, limitations, and future research on cybersecurity.

A State-of-the-Art Review of Malware Attack Trends and Defense Mechanism.