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Uniqueness of the macromolecular crystallographic phase problem
Author(s) -
Millane Rick P.,
Arnal Romain D.
Publication year - 2015
Publication title -
acta crystallographica section a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.742
H-Index - 83
ISSN - 2053-2733
DOI - 10.1107/s2053273315015387
Subject(s) - phase problem , uniqueness , phaser , macromolecule , symmetry (geometry) , envelope (radar) , phase (matter) , crystallography , constraint (computer aided design) , ab initio , physics , space (punctuation) , unit (ring theory) , molecule , molecular physics , chemistry , mathematics , computer science , geometry , mathematical analysis , quantum mechanics , diffraction , optics , telecommunications , biochemistry , radar , mathematics education , operating system
Uniqueness of the phase problem in macromolecular crystallography, and its relationship to the case of single particle imaging, is considered. The crystallographic problem is characterized by a constraint ratio that depends only on the size and symmetry of the molecule and the unit cell. The results are used to evaluate the effect of various real‐space constraints. The case of an unknown molecular envelope is considered in detail. The results indicate the quite wide circumstances under which ab initio phasing should be possible.