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A new polymorph of 1‐hydroxy‐2‐naphthoic acid obtained during failed co‐crystallization experiments
Author(s) -
Zhang Qi,
Li Meiqi,
Mei Xuefeng
Publication year - 2015
Publication title -
acta crystallographica section b
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.604
H-Index - 33
ISSN - 2052-5206
DOI - 10.1107/s2052520614026134
Subject(s) - crystallization , salt (chemistry) , chemistry , crystallography , stereochemistry , chemical engineering , organic chemistry , engineering
Pharmaceutical salt‐forming acid 1‐hydroxy‐2‐naphthoic acid (HNA) is widely used in pharmaceutical co‐crystal preparation. In this work, we report a new polymorph of HNA obtained during attempted co‐crystallization experiments. The reported form and the new form were fully characterized and their thermodynamic relationship was also established to be monotropic with the new form being the more stable form.