Open AccessNeural compensation in presymptomatic hAPP mouse models of Alzheimer's disease
Author(s) -
Martine Ammassari–Teule
Publication year - 2020
Publication title -
learning and memory
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.228
H-Index - 136
eISSN - 1549-5485
pISSN - 1072-0502
DOI - 10.1101/lm.050401.119
Subject(s) - neuroscience , cognitive reserve , cognition , biological neural network , psychology , compensation (psychology) , disease , perspective (graphical) , cognitive impairment , medicine , pathology , computer science , artificial intelligence , psychoanalysis
Largely inspired from clinical concepts like brain reserve, cognitive reserve, and neural compensation, here we review data showing how neural circuits reorganize in presymptomatic and early symptomatic hAPP mice to maintain memory intact. By informing on molecular alterations and compensatory adaptations which take place in the brain before mice show cognitive impairments, these data can help to identify ultra-early disease markers that could be targeted in a therapeutic perspective aimed at preventing rather than treating cognitive deterioration.