Open AccessIn vivo activity of co-trimoxazole combined with colistin against Acinetobacter baumannii producing OXA-23 in a Galleria mellonella model
Author(s) -
Mahmoud A F Khalil,
Sawsan S. Moawad,
Enas Hefzy
Publication year - 2019
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000872
Subject(s) - galleria mellonella , acinetobacter baumannii , colistin , microbiology and biotechnology , in vivo , acinetobacter , biology , antibiotics , bacteria , virulence , pseudomonas aeruginosa , gene , genetics
Acinetobacter baumannii is a critical nosocomial pathogen. A. baumannii infections have become a grave challenge due to their ability to develop resistance to different antimicrobial agents. The current study aimed to evaluate the potential synergism and bactericidal activity of a combination of colistin and cotrimoxazole against carbapenem-resistant A. baumannii (CRAB) in a Galleria mellonella model.