Open AccessActivated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression
Author(s) -
Zhen Wang,
Deng Liu,
Qi Yan,
Fang Liu,
Mengting Zhan,
Shunli Qi,
Qi Fang,
Ling Yao,
Weizhi Wang,
Ruixin Zhang,
Jian Du,
Lijian Chen
Publication year - 2022
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000004156
Subject(s) - liver injury , reperfusion injury , cancer research , downregulation and upregulation , medicine , immunology , pharmacology , ischemia , biology , biochemistry , gene
Hepatic ischemia-reperfusion (I/R) injury is the main factor affecting the morbidity and mortality associated with perioperative complications of liver transplantation and major hepatectomy. AXL is a member of the TYRO3, AXL, MERTK family and is involved in immune and apoptosis processes in multiple organs. However, the role of AXL in hepatic I/R injury remains to be elucidated.