Open AccessPlasma and Mucosal HIV Viral Loads Are Associated With Genital Tract Inflammation in HIV-Infected Women
Author(s) -
Betsy C. Herold,
Marla J. Keller,
Qiuhu Shi,
Donald R. Hoover,
Colleen Carpenter,
Ashley Huber,
Urvi M. Parikh,
Kathy Agnew,
Howard Minkoff,
Christine Colie,
Marek Nowicki,
Gypsyamber D’Souza,
D. Heather Watts,
Kathryn Anastos
Publication year - 2013
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e3182961cfc
Subject(s) - viral load , immunology , medicine , proinflammatory cytokine , chemokine , inflammation , systemic inflammation , human immunodeficiency virus (hiv)
Systemic and mucosal inflammation may play a role in HIV control. A cross-sectional comparison was conducted among women in the Women's Interagency HIV Study to explore the hypothesis that compared with HIV-uninfected participants, women with HIV, and, in particular, those with high plasma viral load (PVL) have increased levels of mucosal and systemic inflammatory mediators and impaired mucosal endogenous antimicrobial activity.