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The purpose of this study was to explore the negative influence coagulation  factor V  ( FV ) 1691G&gt;A polymorphism had on the risk and prognosis of lower extremity deep venous thrombosis (LDVT) in Chinese Han population.  A total of 348 patients with LDVT (LDVT group) and 398 healthy individuals (control group) were selected to further this study. A polymerase chain reaction-restriction fragment length polymorphism method was used to analyze the  FV  gene 1691G&gt;A polymorphism; coagulation and anticoagulation indexes of patients with LDVT were detected as a result. A 3-year follow-up and logistic regression analysis were conducted to determine the corresponding correlations between  FV  gene and LDVT.  In comparison with the control group, the frequencies of GA and AA genotypes and A allele of 1691G&gt;A polymorphism significantly increased in the LDVT group. Also, in comparison with patients with LDVT carrying GG genotype of  FV  gene 1691G&gt;A polymorphism, the following activities reduced significantly: prothrombin time, activated partial thromboplastin time, fibrinogen, protein C, and protein S, while activated protein C resistance and lupus anticoagulant positive rate increased in patients carrying A allele (GA + AA). Logistic regression analysis indicated that  FV  gene 1691G&gt;A polymorphism, total cholesterol, low-density lipoprotein cholesterol, and LDVT family histories were all closely related with LDVT and were subsequent independent risk factors for LDVT. Moreover, patients with LDVT carrying A allele (GA + AA) had both higher patency and recurrence rates than those carrying GG genotype.   FV  gene 1691G&gt;A polymorphism may be associated with both the risk and prognosis of LDVT, potentially being a useful index for monitoring LDVT prognosis and risk.

medicine

Coagulation factor V gene 1691G&gt;A polymorphism as an indicator for risk and prognosis of lower extremity deep venous thrombosis in Chinese Han population