Open AccessMature plasmacytoid dendritic cells associated with acute myeloid leukemia show similar genetic mutations and expression profiles to leukemia cells
Author(s) -
Xiaoyuan Gong,
Chunhong Li,
Ying Wang,
Qing Rao,
Yingchang Mi,
Min Wang,
Hui Wei,
Jianxiang Wang
Publication year - 2022
Publication title -
blood science
Language(s) - English
Resource type - Journals
ISSN - 2543-6368
DOI - 10.1097/bs9.0000000000000097
Subject(s) - myeloid leukemia , myeloid , biology , cd34 , haematopoiesis , progenitor cell , clone (java method) , cd117 , runx1t1 , cancer research , immunophenotyping , immunology , flow cytometry , stem cell , gene , gene expression , genetics
Mature plasmacytoid dendritic cells (pDCs) proliferation associated with myeloid neoplasms (MPDMN) are recognized as a neoplasm related to fully differentiated pDCs. Although it has been reported for many years, the genomic landscape of MPDMN is poorly understood.