Open AccessCalcineurin Inhibitors, but not Rapamycin, Reduce Percentages of CD4+CD25+FOXP3+ Regulatory T Cells in Renal Transplant Recipients
Author(s) -
David San Segundo,
J.C. Ruiz,
María José María e Izquierdo,
Gema FernándezFresnedo,
C. Gómez-Alamillo,
Ramón Merino,
M. Isabel Benito,
Eva Cacho,
Emilio Rodrigo,
Rosa Palomar,
Marcos López-Hoyos,
Manuel Arias
Publication year - 2006
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000229473.95202.50
Subject(s) - calcineurin , immunosuppression , foxp3 , medicine , transplantation , il 2 receptor , sirolimus , kidney , immunology , kidney transplantation , interleukin 7 receptor , t cell , immune system
Immunosuppression in renal transplantation, although manageable in the short-term, is a major hurdle for long-term graft survival. Recently, increased frequencies of CD4CD25 regulatory T cells (Tregs) have been described as an additional mechanism that induces alloimmune tolerance.